ACCESS: A Multicenter, Phase II Trial of HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide for Patients with Hematologic Malignancies

What's the purpose of the trial?

This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be used for for graft versus host disease (GVHD) prophylaxis. This trial will study how well this treatment works in patients with hematologic malignancies.

Trial status

Accepting patients

Phase 2
Last Updated
1 month ago
Am I Eligible

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Busulfan is a chemotherapy cancer medication that interferes with the growth and spread of cancer cells in the body.
  • Fludarabine is a chemotherapy agent used in the treatment of cancer.
  • Radiation is used to fight may types of cancer including multiple myeloma. Cancer cells multiply faster than normal cells in the body. Radiation is most harmful to quickly growing cells, so radiation therapy damanges cancer cells more than normal cells. This stops cancer cells from growing and dividing and leads to cell death.
  • Melphalan is a chemotherapy medication used in the treatment of multiple myeloma.
  • Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.

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