Case Comprehensive Cancer Center

Case Western Reserve University

Cleveland, OH

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Accepting patients

Azacitidine and Decitabine

Proof-Of-Concept Study of Metabolically Optimized, Non-Cytotoxic 5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies
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  • Hypomethylating Agents (HMA)
  • Phase 1

Accepting patients

Connect® Myeloid: The Myelofibrosis (MF), Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease Registry
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  • Observational Trial
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Accepting patients

Ivosidenib (AG120)

Phase Ib/II Investigator Initiated Study of the IDH1-Mutant Inhibitor Ivosidenib (AG120) With the BCL2 Inhibitor Venetoclax +/- Azacitidine in IDH1-Mutated Hematologic Malignancies
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  • BCL-2 Inhibitor
  • Hypomethylating Agents (HMA)
  • IDH1 Inhibitor
  • Phase 1/2
  • Has results

Accepting patients

NK Cells Plus Vactosertib

A Phase Ib Study to Evaluate Safety and Persistence of ex Vivo Expanded Universal Donor NK Cells in Combination With IL-2 and TGFbeta Receptor I Inhibitor Vactosertib in Patients With Locally Advanced/Metastatic Colorectal Cancer, Gastric/Esophageal Cancer, and Relapsed/Refractory Hematologic Malignancies
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  • Kinase Inhibitor
  • Natural Killer Cells (Allogeneic)
  • Phase 1