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Accepting patients

NK Cells Plus Vactosertib

A Phase Ib Study to Evaluate Safety and Persistence of ex Vivo Expanded Universal Donor NK Cells in Combination With IL-2 and TGFbeta Receptor I Inhibitor Vactosertib in Patients With Locally Advanced/Metastatic Colorectal Cancer and Relapsed/Refractory Hematologic Malignancies
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  • Kinase Inhibitor
  • Natural Killer Cells (Allogeneic)
  • Phase 1

Accepting patients

LP-118

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory NHL, RT, MM, T-PLL, Acute Leukemia (AML, ALL), MDS, MDS/MPN, and MF
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  • BCL-2 Inhibitor
  • Bcl/xL Inhibitor
  • Phase 1
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Accepting patients

Canakinumab

A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia
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  • Monoclonal Antibody
  • Phase 2
  • Has results

Accepting patients

CPX-351 Plus Gemtuzumab Ozogamicin

A Pilot Study of Liposomal Cytarabine and Daunorubicin (CPX-351) in Combination With Gemtuzumab Ozogamicin (GO) in Relapsed Refractory Patients With Acute Myeloid Leukemia (AML) and Post-Hypomethylating Agent (Post-HMA) Failure High-Risk Myelodysplastic Syndrome (HR-MDS)
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  • Antibody Drug Conjugate (ADC)
  • Phase 2
  • Has results

Accepting patients

Orca-T

A Randomized Phase III Trial of Patients With Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation With Either Orca-T, a T-cell-Depleted Graft With Additional Infusion of Conventional T Cells and Regulatory T Cells, or Standard-of-Care Allogeneic Graft
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  • Allogeneic Stem Cell Transplant
  • T Cell (Allogeneic)
  • Phase 3
  • Has results

Accepting patients

Imetelstat Expanded Access

Expanded Access Treatment With Imetelstat For Adult Participants With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Are Transfusion-Dependent And Have Failed to Respond or Have Lost Response or Are Ineligible For Erythropoiesis-Stimulating Agents (ESAs)
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  • Telomerase Inhibitor
  • Expanded Access

Accepting patients

Praise IR

Phase 2 Study of Personalized r-ATG Dosing to Improve Survival through Enhanced Immune Reconstitution in Pediatric and Adult Patients Undergoing ex vivo CD34-Selected Allogeneic HCT (PRAISE IR)
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  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

ACCESS

ACCESS: A Multicenter, Phase II Trial of HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide for Patients with Hematologic Malignancies
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  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

Azacitidine Plus Best Supportive Care

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Participants With International Prognostic Scoring System Revised (IPSS-R) Low- or Intermediate-risk Myelodysplastic Syndrome (MDS)
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  • Hypomethylating Agents (HMA)
  • Phase 2/3

Accepting patients

SELECT MDS-1

A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Tamibarotene Plus Azacitidine Versus Placebo Plus Azacitidine in Newly Diagnosed, Adult Patients Selected for RARA-positive Higher-risk Myelodysplastic Syndrome (SELECT MDS-1)
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  • Hypomethylating Agents (HMA)
  • RAR-α / NR1B1
  • Phase 3
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