Optimized Cord Blood Transplant
Optimized Cord Blood Transplantation for the Treatment of High-Risk Hematologic Malignancies in Adults and Pediatrics
What's the purpose of the trial?
This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with hematologic diseases. Giving chemotherapy, such as cyclophosphamide, fludarabine and thiotepa, and TBI before a donor cord blood transplant (CBT) helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving cyclosporine and mycophenolate mofetil after transplant may stop this from happening in patients with high-risk hematologic diseases.
Trial status
Accepting patients
Phase
Phase 2
Enrollment
54
Last Updated
2 weeks ago
Participating Centers
There are 2 centers participating in this trial. Enter a location below to find the closest center.
Experimental Treatments
Learn more about the experimental treatments being evaluated in this clinical trial.
- Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
- Cyclosporine is a drug that suppresses the immune system. It may be used in patients who have had organ transplants, autoimmune disorders, or graft vs host disease.
- Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
- Mycophenolate Mofetil is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
- Thiotepa is an antineoplastic chemotherapy agent that is used to treat several different kinds of cancer.
Arms / Cohorts
Explore eligibility, treatments and learn more about potential cohorts.
Accepting patients
Accepting patients
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