Massachusetts General Hospital

Accepting patients

MBG453

TIM3 Inhibition With MBG453 for Patients With Lower Risk MDS: an Adaptive Two-Stage Phase II Clinical Trial
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  • Monoclonal Antibody
  • TIM-3
  • Phase 2

Accepting patients

A Controlled Multi-Arm Ph1 Study Evaluating the Safety and Feasibility of TCR Engineered Donor TCells Targeting HA1 (TSC-100) or HA2 (TSC-101) in HLA-A0201 Positive Patients Undergoing Haploidentical Allogeneic Stem Cell Transplantation
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  • T Cell (Allogeneic)
  • Phase 1
  • Has results
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Accepting patients

Phase II Study of Maintenance Ruxolitinib After Allogeneic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) in Complete Remission
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  • JAK2 Inhibitor
  • Maintenance
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 2

Accepting patients

Decitabine/Cedazuridine as Maintenance Therapy

A Phase Ib Study of Oral Decitabine/Cedazuridine as Maintenance Therapy Following Allogeneic Hematopoietic Cell Transplantation for Patients With Myeloid Neoplasms
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  • Cytidine Deaminase Inhibitor
  • Hypomethylating Agents (HMA)
  • Phase 1

Accepting patients

AZD6738

A Phase Ib Study of AZD6738 for Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Progressing on Front-Line Therapy
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  • Kinase Inhibitor
  • Phase 1

Accepting patients

CC-91633 (BMS-986397)

A Phase 1, Open-label, Dose-finding Study of CC-91633 (BMS-986397) in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-Risk Myelodysplastic Syndromes
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  • CELMoD
  • Phase 1

Accepting patients

CLN-049

A Phase 1, Open-label, Preliminary Pharmacokinetics (PK) and Safety Study of CLN-049 (An Fms-like Tyrosine Kinase 3 [FLT3] x Cluster of Differentiation 3 [CD3] Bispecific T Cell Engager) in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
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  • FLT3
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1

Accepting patients

LYT-200

A Phase 1 Open-label, Multi-center Study of the Safety, Pharmacokinetics (PK), and Anti-tumor Activity of LYT- 200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)
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  • Monoclonal Antibody
  • Galectin-9 Protein
  • Phase 1

Accepting patients

Bone Marrow & Kidney Transplant

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders
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  • Allogeneic Stem Cell Transplant
  • Phase 2

Accepting patients

NC525

A Phase 1, Open-Label, Safety, Tolerability, And Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms
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  • Monoclonal Antibody
  • Phase 1

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