A Phase 1/2, Open Label, Multicenter Study to Investigate the Safety and Efficacy of Fadraciclib (CYC065), an Oral CDK 2/9 Inhibitor, in Subjects With Leukemias or Myelodysplastic Syndrome (MDS)

What's the purpose of the trial?

This is a 2-part, phase 1/2, open-label, multicenter study designed to evaluate the safety and efficacy of fadraciclib (formerly CYC065) administered orally BID. This study consists of Phase 1 and Phase 2 components in subjects with Leukemia or Myelodysplastic syndrome (MDS) who have progressed despite having standard therapy or for which no standard therapy exists.
Trial status

Not currently accepting

Phase
Phase 1/2
Enrollment
210
Last Updated
1 month ago
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Participating Centers

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Experimental Treatments

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  • Fadraciclib is an oral and intravenous CDK (cyclin-dependent kinase) inhibitor being studied for use in several different cancers.

Arms / Cohorts

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Accepting patients

Phase 2

Not currently accepting

Phase I Dose escalation

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