Graft Versus Host Disease-Reduction Strategies
A Phase II Randomized Controlled Trial Comparing GVHD-Reduction Strategies for Allogeneic Peripheral Blood Transplantation (PBSCT) for Patients With Acute Leukemia or Myelodysplastic Syndrome: Selective Depletion of CD45RA+ Naïve T Cells (TND) vs. Post-Transplantation Cyclophosphamide (PTCy)
What's the purpose of the trial?
Accepting patients
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Participating Centers
There are 3 centers participating in this trial. Enter a location below to find the closest center.
Experimental Treatments
Learn more about the experimental treatments being evaluated in this clinical trial.
- Allogeneic Stem Cell Transplant is a type of stem cell transplant that utilizes a donor's pre-collected stem cells to rescue the bone marrow from the toxic effects of very high dose chemotherapy.
- Busulfan is a chemotherapy cancer medication that interferes with the growth and spread of cancer cells in the body, and may be used in the treatment of many different cancers.
- Cyclophosphamide is a chemotherapy agent used in the treatment of cancer.
- Cyclosporine is a drug that suppresses the immune system. It may be used in patients who have had organ transplants, autoimmune disorders, or graft vs host disease.
- Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
- Methotrexate is a chemotherapy medication that may be used in the treatment of many different cancers.
- Sirolimus is an immunosuppressive medication used in several indications, including to help prevent rejection in patients who have had a transplant.
- Tacrolimus is an immunosuppressive medication used to help prevent rejection in patients who have had a transplant.
- Thiotepa is an antineoplastic chemotherapy agent that is used to treat several different kinds of cancer.
Arms / Cohorts
Explore eligibility, treatments and learn more about potential cohorts.
Accepting patients
Accepting patients
Accepting patients
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