ARC-T Cells Plus SPRX002

Master Protocol for the Phase 1 Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome, Including Long-term Safety Follow-up

What's the purpose of the trial?

The purpose of this study is to evaluate the safety and preliminary activity of ARC-T cells and SPRX002 in participants with relapsed or refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS)
Trial status

Accepting patients

Phase
Phase 1
Enrollment
24
Last Updated
1 month ago
Am I Eligible

Participating Centers

There are 5 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • ARC-T Cells are a D-Domain-based genetically modified CAR T-cell therapy.
  • SPRX002 is an antigen receptor that binds to CD123 on cancer cells and may help other drugs better recognize cancer cells.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

CD123-Specific Adapter (SPRX002) + Universal CAR-Modified T Cell (ARC-T Cells)

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