SL-172154

An Open-Label Phase 1a/1b Dose Escalation and Expansion Cohort Study of SL-172154 (SIRPα-Fc-CD40L) in Combination With Azacitidine or With Azacitidine and Venetoclax for the Treatment of Subjects With Higher-Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)

Arms / Cohorts

Experimental:SL-172154

Accepting patients

Experimental:Untreated MDS Patients: SL-172154 + Azacitidine (Dose Escalation)

Accepting patients

Experimental:R/R MDS Patients: SL-172154 + Azacitidine (Dose Escalation)

Accepting patients

Experimental:Untreated MDS Patients: SL-172154 + Azacitidine (Dose Expansion)

Accepting patients

Experimental:SL-172154 + Azacitidine + Venetoclax

Accepting patients

Experimental, Part D:Untreated High-Risk MDS Patients: SL-172154

Accepting patients

Real People. Real Support.

Need help connecting with this clinical trial? We're here to help!

Print this trial to share with your doctor.

We can help answer any questions and connect you (or your patient) with the study team.

Schedule a time that is convenient and we’ll call you to see how we can help you and your patient.