APG-2575 Plus Azacitidine

A Phase Ib/II Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML), Mixed Phenotype Acute Leukemia (MPAL), Chronic Myelomonocytic Leukemia (CMML) and Higher-Risk Myelodysplastic Syndrome (MDS

What's the purpose of the trial?

This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy and PK of APG-2575 in combination with Azacitidine in the patients with AML/MPAL or MDS/CMML. The study consists of dose escalation (Part I) and dose expansion phase (Part II)

Trial status

Accepting patients

Phase

Phase 1/2

Enrollment

Last Updated

1 month ago

Am I Eligible

Participating Centers

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Experimental Treatments

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Lisaftoclax is a BCL-2 inhibitor that is being studied for use in several different cancers.

Arms / Cohorts

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Accepting patients

APG2575 + Azacitidine

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