LIMBER

A Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms

What's the purpose of the trial?

The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of INCB057643 as monotherapy or combination with ruxolitinib for participants with myelofibrosis and other myeloid neoplasms.
Trial status

Accepting patients

Phase
Phase 1
Enrollment
231
Last Updated
2 weeks ago
Am I Eligible

Participating Centers

There are 17 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • INCB057643 is a small molecule BET inhibitor that is being studied for use in several different indications. 
  • Ruxolitinib is a tyrosine kinase inhibitor in development for the treatment of several different blood cancers.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

Part 1 : INCB057643 Monotherapy

Accepting patients

Part 2 : INCB057643 Combination with Ruxolitinib

Real People. Real Support.

Need help connecting with this clinical trial? We're here to help!

Print this trial to share with your doctor.

We can help answer any questions and connect you (or your patient) with the study team.

Schedule a time that is convenient and we’ll call you to see how we can help you and your patient.