Curcumin vs. Placebo

A Phase 2, Double-blind, Randomized Study to Compare the Effect of Curcumin Versus Placebo on Inflammatory Cytokines, Symptoms and Disease Parameters in Clonal Cytopenia of Undetermined Significance (CCUS), Low-Risk Myelodysplastic Syndrome (LR-MDS), and Myeloproliferative Neoplasms (MPNs)

What's the purpose of the trial?

This phase II trial evaluates how a curcumin supplement (C3 complex/Bioperine) changes the inflammatory response and symptomatology in patients with clonal cytopenia of undetermined significance (CCUS), low risk myelodysplastic syndrome (LR-MDS), and myeloproliferative neoplasms (MPN). Chronic inflammation drives disease development and contributes to symptoms experienced by patients with CCUS, LR-MDS, and MPN. Curcumin has been shown to have anti-inflammatory and anti-cancer properties and has been studied in various chronic illnesses and hematologic diseases.
Trial status

Accepting patients

Phase
Phase 2
Enrollment
30
Last Updated
1 month ago
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Participating Centers

There is one center participating in this trial. Enter a location below to view the distance.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

  • Curcumin is a bright yellow chemical produced by plants of the Curcuma longa species. Ongoing clinical trials are exploring the anticancer effects of curcumin. 
  • Piperine is an alkaloid present in black pepper, one of the most widely used spices, in long pepper, and other Piper species fruits belonging to the family of Piperaceae. Ongoing clinical trials are exploring the anticancer effects of Piperine.
  • Placebo is a substance that has no therapeutic effect and can be used as a control in testing new drugs in clinical trials.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

C3 Complex/Bioperine

Accepting patients

Placebo

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