Treosulfan and Fludarabine Pre-Transplant

An Open-label, Non-randomized, Prospective Trial to Evaluate the Effect of Renal Function Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics in Patients With AML or MDS Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

What's the purpose of the trial?

This study aim is to assess, if treosulfan pharmacokinetics are influenced by declined renal function and by race/ethnicity of patients. The study also aims to determine an appropriate safe dose of treosulfan, when patient's renal function is impaired. The participants of this study are undergoing allogenic hematopoietic stem cell transplantation for treatment of acute myeloid leukemia or myelodysplastic syndrome.

Trial status

Accepting patients

Phase

Phase 1

Enrollment

Last Updated

2 months ago

Am I Eligible

Participating Centers

There are 4 centers participating in this trial. Enter a location below to find the closest center.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

Fludarabine is a chemotherapy medication that may be used in the treatment of many different cancers.
Treosulfan is a chemotherapy medication given to people before stem cell transplantation.

Arms / Cohorts

Explore eligibility, treatments and learn more about potential cohorts.

Accepting patients

Treosulfan + Fludarabine

Real People. Real Support.

Need help connecting with this clinical trial? We're here to help!

Print Report

Print this trial to share with your doctor.

(888) 803-1766

We can help answer any questions and connect you (or your patient) with the study team.

Schedule Call

Schedule a time that is convenient and we’ll call you to see how we can help you and your patient.