MyeloMATCH Master Protocol

Master Screening and Reassessment Protocol (MSRP) for the NCI MyeloMATCH Clinical Trials

Arms / Cohorts

Active Comparator:MM1MDS-A01 Arm A (ASTX727)

Accepting patients

Experimental:MM1MDS-A01 Arm B (ASTX727, enasidenib)

Accepting patients

Experimental MM1OA-EA02:MM1OA-EA02 Regimen 1 (azacitidine, venetoclax)

Accepting patients

Experimental:MM1OA-EA02 Regimen 2 (azacitidine, venetoclax, gilteritinib)

Accepting patients

Experimental:MM1OA-EA02 Regimen 3 (azacitidine, venetoclax, gilteritinib)

Accepting patients

Experimental:MM1YA-CTG01 Arm I (daunorubicin, cytarabine, venetoclax)

Accepting patients

Experimental:MM1YA-CTG01 Arm II (azacitidine, venetoclax)

Accepting patients

Active Comparator:MM1YA-CTG01 Arm III (daunorubicin, cytarabine)

Accepting patients

Active Comparator:MM1YA-S01 Arm I (cytarabine, daunorubicin)

Accepting patients

Experimental:MM1YA-S01 Arm II (cytarabine, daunorubicin, venetoclax)

Accepting patients

Experimental:MM1YA-S01 Arm III (azacitidine, venetoclax)

Accepting patients

Experimental:MM1YA-S01 Arm IV (Vyxeos)

Accepting patients

Experimental:MM1YA-S01 Arm V (Vyxeos, venetoclax)

Accepting patients

Active Comparator:MM2YA-EA01 Arm A (cytarabine)

Accepting patients

Experimental:MM2YA-EA01 Arm B (cytarabine, venetoclax)

Accepting patients

Experimental:MM2YA-EA01 Arm C (Vyxeos, venetoclax)

Accepting patients

Experimental:MM2YA-EA01 Arm D (azacitidine, venetoclax)

Accepting patients

Experimental:Screening (mutation carrier screening)

Accepting patients

Experimental:TAP (SOC treatment, mutation carrier screening)

Accepting patients

Active Comparator:MM1OA-S03 Arm 1 (ASTX727, venetoclax)

Accepting patients

Experimental:MM1OA-S03 Arm 2 (ASTX727, venetoclax, enasidenib)

Accepting patients

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