Lisaftoclax

A Global Multicenter, Double-blind, Randomized, Registrational Phase 3 Study of Lisaftoclax (APG-2575) in Combination With Azacitidine (AZA) in Patients With Newly Diagnosed Higher Risk Myelodysplastic Syndrome (HR-MDS) (GLORA-4).

What's the purpose of the trial?

A global multicenter, randomized, double-blind, placebo-controlled, pivotal phase III study. To evaluate overall survival (OS) of Lisaftoclax (APG-2575) combined with azacitidine (AZA) vs. placebo combined with azacitidine in newly diagnosed patients with HR-MDS.

Trial status

Not yet accepting

Phase

Phase 3

Enrollment

464

Last Updated

1 month ago

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Participating Centers

There is one center participating in this trial. Enter a location below to view the distance.

Experimental Treatments

Learn more about the experimental treatments being evaluated in this clinical trial.

Azacitidine is a type of chemotherapy called a hypomethylating agent that interferes with the growth and spread of cancer cells in the body.
Lisaftoclax is a BCL-2 inhibitor that is being studied for use in several different cancers.
Placebo is a substance that has no therapeutic effect and can be used as a control in testing new drugs in clinical trials.

Arms / Cohorts

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Not yet accepting

Lisaftoclax (APG-2575) combined with Azacitidine

Not yet accepting

Placebo combined with Azacitidine

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