Orca-T
A Phase 2 Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
What's the purpose of the trial?
This study will evaluate the safety, tolerability, and efficacy of Orca-T in participants undergoing reduced intensity or non-myeloablative allogeneic hematopoietic cell transplantation (alloHCT) for hematologic malignancies. Orca-T is an allogeneic stem cell and T-cell immunotherapy biologic manufactured for each patient (transplant recipient) from the mobilized peripheral blood of a specific, unique donor. It is composed of purified hematopoietic stem and progenitor cells (HSPCs), purified regulatory T cells (Tregs), and conventional T cells (Tcons).
Trial status
Accepting patients
Phase
Phase 2
Enrollment
80
Last Updated
Participating Centers
There are 5 centers participating in this trial. Enter a location below to find the closest center.
Experimental Treatments
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- Orca-T is a T cell therapy made from stem and T cells. Orca-T is made from allogeneic donors, and is specialized to try and minimize allogeneic transplant side effects.
Arms / Cohorts
Explore eligibility, treatments and learn more about potential cohorts.
Accepting patients
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